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已知,促性腺激素释放激素(GnRH)能促进人类的泌乳素释放。有报导,在周期正常妇女,绝经后妇女或卵巢切除的妇女,静脉点滴GnRH(0.2μg/分,连续3.5小时)可引起明显的泌乳素释放。这证明,药理剂量的GnRH可引起正常人的泌乳素释放。最近,在性腺功能低下妇女,观察到非药理低剂量的GnRH也可引致泌乳素释放。高雌激素水平似可促进药理剂量GnRH的促泌乳素释放作用。本文旨在评价正常月经周期中,低剂量(10μg)GnRH的促泌乳素释放作用。选择70例17～42岁周期正常的妇女为受试者。规律采血并根据LH、FSH、雌二醇及孕酮水平的
It is known that gonadotropin-releasing hormone (GnRH) promotes prolactin release in humans. It has been reported that intravenous drip of GnRH (0.2 μg / min for 3.5 hours) in normal women, postmenopausal women or ovariectomized women can cause significant prolactin release. This proves that pharmacological doses of GnRH can cause normal human prolactin release. Recently, in hypogonadal women, the observed non-pharmacological low doses of GnRH can also cause prolactin release. High estrogen levels may promote prolactin release of pharmacological doses of GnRH. This article aims to evaluate the prolactin release of low-dose (10 μg) GnRH during the normal menstrual cycle. Seventy women aged 17 ~ 42 years with normal cycle were selected as subjects. Regular blood sampling and LH, FSH, estradiol and progesterone levels