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生存蛋白（survivin）基因是凋亡抑制蛋白家族的新成员，也是目前发现的功能最强大的凋亡抑制蛋白。过去有关survivin的研究主要集中在皮肤恶性肿瘤领域（如恶性黑素瘤、基底细胞瘤、鳞状细胞癌、皮肤瘢痕癌、鲍温病），近期研究表明，其在皮肤良性肿瘤中（如色素痣、光化性角化病、脂溢性角化病、乳头状瘤、尖锐湿疣、鲍温样丘疹病）同样也有阳性表达。目前，这方面的研究已取得了明显进展，未来，survivin将有可能成为皮肤肿瘤新的临床诊断标准与治疗靶点。“,”Survivin is a new member of the inhibitors of apoptosis protein(IAP),which is also currently found as the strongest cell apoptosis inhibitor.The past research about survivin focused mainly on malignant skin tumors such as malignant melanoma,basal cell carcinoma,squamous cell carcinoma,skin scar carcinoma, and Bowen disease.The recent studies show that survivin also expresses in benign skin tumors such as nevus pigmentosus,actinic keratosis,seborrheic keratosis,papillary epithelioma,condyloma acuminate,and Bowe-noid papulosis.The study of survivin in expression of skin tumors has made great progress recently,and sur-vivin may prove to be a new diagnostic criteria and therapeutic target of skin tumors in the future .