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肝微粒体酶对毒物在体内的生物转化具有重要的意义,在毒理学中日益受到重视。本文用巴比妥盐诱导法观察该酶对麦草畏的作用。大鼠先经苯巴比妥予处理后,麦草畏对动物的毒性与对照组相比,雄鼠下降3.8倍,雌鼠下降2.5倍。结果表明麦草畏在大鼠体内转化与肝微粒体酶的解毒作用有关。如先给大鼠长期接触麦草畏,再用异戊巴比妥测定睡眠时间,则染毒组大鼠睡眠时间明显缩短,且有剂量效应关系,说明麦草畏对肝微粒体酶有刺激作用,提示该农药属肝微粒体酶诱导剂。
Liver microsomal enzymes have important implications for the biotransformation of toxicants in the body and are increasingly valued in toxicology. The effect of this enzyme on dicamba was observed using barbiturate induction method. After the rats were treated with phenobarbital, the toxicity of dicamba to the animals was 3.8 times lower in males and 2.5 times in females compared to the control group. The results showed that the conversion of dicamba in rats was related to the detoxification of liver microsomal enzymes. If rats were exposed to dicamba for a long period of time, and isoprenaline was used for the determination of sleep time, sleep time was significantly shortened in rats exposed to the drug, and there was a dose-effect relationship, indicating that dicamba had stimulatory effects on liver microsomal enzymes. The pesticide is a liver microsomal enzyme inducer.