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目的:探讨内源性促红细胞生成素(EPO)在慢性心力衰竭(CHF)及CHF贫血发病中的作用及临床价值。方法:采用放射性免疫分析法测定117例CHF患者和40例非CHF患者血浆EPO水平,分析EPO水平与心功能分级、贫血以及CHF患者预后的关系。结果:心功能II～IV患者EPO水平显著上升,与对照组比较均有显著性差异(P<0.05);EPO水平随着心功能分级增高而逐渐上升,在各级间比较有显著性差异(P<0.05);CHF伴贫血患者EPO水平随着心功能分级增高和贫血程度的加重而逐渐上升,在各级间比较有显著性差异(P<0.05);死亡组EPO水平显著高于存活组,而Hb水平显著低于存活组,相比较有显著性差异(P<0.05)。结论:CHF患者和CHF伴贫血患者内源性EPO水平升高,EPO水平的上升与CHF患者病情严重程度有关,并且是CHF患者预后不良的预测指标。
Objective: To investigate the role and clinical value of endogenous erythropoietin (EPO) in the pathogenesis of chronic heart failure (CHF) and CHF anemia. Methods: Plasma EPO levels were measured in 117 CHF patients and 40 non-CHF patients by radioimmunoassay. The relationship between EPO levels and cardiac function, anemia and the prognosis of CHF patients was analyzed. Results: The levels of EPO in patients with cardiac function II-IV increased significantly (P <0.05), while the levels of EPO increased gradually with the increase of heart function, with significant difference at all levels P <0.05). EPO levels in patients with CHF and anemia increased gradually with the increase of heart function and the degree of anemia, with significant difference at all levels (P <0.05). EPO levels in death patients were significantly higher than those in survivors , While the Hb level was significantly lower than the survival group, compared with significant difference (P <0.05). CONCLUSIONS: Endogenous EPO levels are elevated in patients with CHF and CHF with anemia. Elevated EPO levels are associated with the severity of CHF and are predictive of poor prognosis in patients with CHF.