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扑热息痛是一种非甾体类的镇痛解热药。首次问世于1956年,此后它作为阿司匹林的安全替代药日益盛行。由于其广泛应用,近年来,意外和自杀性过量的发生率均已增加。很多患者、甚至医生都不了解扑热息痛过量的有害作用。已有报道仅10g的剂量可引起肝功能衰竭。在英国,因扑热息痛过量引起的肝功能衰竭多于其他原因。 扑热息痛引起肝细胞坏死是由于直接对肝细胞的毒性作用。肝脏损害与剂量有关,并可预测。一般发生于过大剂量和自杀意图等,但也曾发现长期服用低剂量后而产生慢性肝细胞坏死。原有肝脏疾病的患者更易受本品对肝细胞毒性作用的影响。
Paracetamol is a non-steroidal analgesic antipyretic. It first appeared in 1956 and has since become increasingly popular as a safe alternative to aspirin. Due to their widespread use, the incidence of accidental and suicidal overdoses has increased in recent years. Many patients, even doctors, are not aware of the detrimental effects of paracetamol overdose. It has been reported that only a dose of 10 g can cause liver failure. In the UK, liver failure due to an overdose of paracetamol is more common than other causes. Paracetamol causes hepatocyte necrosis due to the toxic effects on hepatocytes. Liver damage is dose-related and predictable. Generally occurs in excessive dose and suicidal intent, but also found that long-term use of low doses of chronic liver cell necrosis. Patients with liver disease are more susceptible to the effects of this product on hepatotoxic effects.