药物治疗的成败关键,常与给药方案有关。为获得预期疗效,须确定合适的剂量和给药间隔时间。然而,从给药到生效是一个复杂过程,受很多因素影响,尤其是药物的个体差异性,常使临床上不能根据剂量来预测机体的反应。因此,只有不断加深认识药物体内过程的规律性,实施必要的“个体化”给药方案,才能逐步改变以往主要凭经验确定最适剂量的做法。 The key to the success of drug treatment, often associated with drug delivery programs. In order to obtain the desired therapeutic effect, the appropriate dose and dosing interval must be determined. However, the process from administration to administration is a complex process and is influenced by many factors, especially the individual differences of the drugs, which often make it impossible to predict the response of the body according to the dose clinically. Therefore, only by continuously deepening the understanding of the regularity of the process in the drug body and implementing the necessary “individualized” drug delivery plan can we gradually change the previous practice of mainly determining the optimal dosage by experience.