P-糖蛋白是被mdr-1基因(也称PGY1)编码的一个膜性磷酸糖旦白,高水平mdr-1/P-糖旦白(Pgp)介导的多重耐药(MDR)常使化疗效果受限,它可发生在初发和继发病史中。MDR 已在组织培养系统中进行了研究,然而大多数肿瘤标本中mdr-1/Pgp 表达非常低。为了确定在临床上是否可用常规方法检测到mdr-1/Pgp 表达和测定Pgp 介导的MDR 是否存在可逆性,本文用RNA 杂交、印迹 P-glycoprotein is a membranous phosphogalactone encoded by the mdr-1 gene (also called PGY1) and is often associated with high level of mdr-1 / P-glycoprotein (MDR) -mediated multidrug resistance Chemotherapy is limited and can occur in both primary and secondary medical history. MDR has been studied in tissue culture systems, however, mdr-1 / Pgp expression is very low in most tumor samples. To determine if mdr-1 / Pgp expression can be detected clinically using conventional methods and to determine if Pgp-mediated MDR is reversible, we used RNA hybridization, blotting