常用于临床的病因性预防或根治抗疟药极为有限,只有伯喹对人体间日疟或卵形疟原虫持续组织期有临床疗效,但伯喹的毒性限制了它在预防或治疗上的临床应用。为了寻找新的抗疟药,筛选了近4000个不同结构的化合物,发现其中700多个有活性,现按不同化学结构,分十类简述如下。 Commonly used in clinical etiology of prophylaxis or curative antimalarial drugs is extremely limited, only primaquine has clinical efficacy against persistent vasculature of Plasmodium vivax or Plasmodium ova, but primaquine toxicity limits its clinical utility in prophylaxis or treatment application. In search of a new antimalarial drug, nearly 4,000 compounds of different structures were screened and more than 700 of them were found active. According to different chemical structures, the ten classes are summarized as follows.