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环一磷酸腺苷(cAMP)及环磷酸鸟苷(cGMP)人类和各种动物细胞内具有非常重要的生物学效应的物质。重度呼吸道烧伤极易发生肺水肿,而机体起调控作用的cAMP5和cGMP在血浆、肺组织内含量势必会出现变化,为探讨肺水肿发生机制,特对cAMP和cGMP含量进行动态观察。正常动物血浆cAMP为15.19±1.13pmol/ml,cGMP为10.05±2.60pmol/ml,cAMP/cGMP的比值为1.512。呼吸道烧伤组致伤后血浆cAMP含量逐浙升高,1小时达最高峰值为30.29±3.71pmol/ml,与自身伤前相比相差非常显著(P<
CAMP and cGMP are substances that have very important biological effects in human and various animal cells. Severe respiratory burn prone to pulmonary edema, and the body plays a regulatory role of cAMP5 and cGMP in plasma and lung tissue content is bound to change, in order to explore the mechanism of pulmonary edema, especially cAMP and cGMP content dynamic observation. Normal animals had a plasma cAMP of 15.19 ± 1.13 pmol / ml, a cGMP of 10.05 ± 2.60 pmol / ml and a cAMP / cGMP ratio of 1.512. The plasma cAMP level in the respiratory burn group was higher than that in the pre-injury group (P <0.05), and the highest peak value in one hour was 30.29 ± 3.71 pmol / ml (P <