论文部分内容阅读
①目的 探讨长期口服蒲元胃康胶囊的毒性作用。②方法 Ｗｉｓｔａｒ大鼠３０只，随机分为对照组和蒲元胃康胶囊高、低剂量组，蒲元胃康胶囊高、低剂量组分别以６．６ 和４．０ｇ／ｋｇ 体质量蒲元胃康胶囊对大鼠灌胃，对照组则给予等体积的生理盐水。给药组大鼠用药周期１２０ｄ，观察给药期间大鼠的一般状况和体质量增长、血常规、凝血时间、部分血液生化指标及组织器官等方面的变化。③结果 ３组大鼠一般状况未见明显差异；而大鼠体质量增长、血常规、凝血时间、部分血液生化指标及组织结构等也均未见明显异常（Ｆ＝ ０～２．８９，Ｐ均＞ ０．０５）。④结论蒲元胃康胶囊的毒性较低，临床长期用药较为安全。
Objective To investigate the toxic effects of long-term Puyuan Weikang capsules. 2Methods Thirty Wistar rats were randomly divided into control group and Puyuan Weikang capsule high-dose group and low-dose group. Puyuan Weikang capsule high-dose group and low-dose group were 6.6 and 4.0g/kg body weight respectively. Weikang capsules were intragastrically administered to rats, while the control group was given an equal volume of normal saline. The administration period of rats in the administration group was 120 days. Observe the changes in general conditions and body weight, blood routine, clotting time, some blood biochemical parameters, and tissues and organs of the rats during administration. 3 Results There was no significant difference in the general condition of the rats in the three groups. There was no obvious abnormality in the body weight, blood routine, coagulation time, some blood biochemical parameters, and histological structure in the rats (F= 0 to 2.89, P). Both> 0.05). 4 Conclusions Puyuan Weikang capsule is less toxic, and clinical long-term medication is safer.