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作为转录水平的ＤＮＡ修饰方式之一，ＤＮＡ甲基化（ＤＮＡｍｅｔｈｙｌａｔｉｏｎ）在调节基因表达及维持细胞正常分化中起着重要作用。ＤＮＡ甲基化主要是指胞嘧啶（Ｃｙｔｏｓｉｎｅ，Ｃ）５位碳和腺嘌呤（Ａｄｅｎｉｎｅ，Ａ）Ｎ６位的甲基化，分别形成ｍ５Ｃ和ｍ６Ａ；而
As one of the DNA modification methods at the transcriptional level, DNA methylation plays an important role in regulating gene expression and maintaining normal cell differentiation. DNA methylation mainly refers to the methylation at position 5 of Cytosine (C) and N6 of Adenine (A), forming m5C and m6A, respectively.