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目的探讨肺癌和慢性阻塞性肺疾病(COPD)患者中肺炎衣原体(Cpn)的感染状况。方法应用固相酶联免疫吸附法,对确诊的128例肺癌和126例COPD急性加重期患者进行血清肺炎衣原体抗体IgM,IgG检测,以70例健康人为正常对照组(简称对照组)。结果COPD组肺炎衣原体IgM抗体阳性率(36.5%,46/126)及IgM和/或IgG阳性率(32.8%,42/126),均较肺癌组(分别为21.8%,28/128和23.1%,30/128)及对照组(分别为1.4%,1/70和2.8%,2/70)明显升高(P<0.005),肺癌组IgM阳性率较对照组明显升高(P< 0.005)IgM和/或IgG阳性人数为74例,总感染率为22.8%(74/324)。结论肺癌和COPD患者都是Cpn易感染人群,其Cpn感染主要表现为急性感染。Cpn可能是COPD急性加重和肺癌合并肺部感染的主要病原。
Objective To investigate the infection status of Chlamydia pneumoniae (Cpn) in patients with lung cancer and chronic obstructive pulmonary disease (COPD). Methods Serum anti-Chlamydia pneumoniae IgM and IgG were detected in 128 patients with lung cancer and 126 patients with acute exacerbation of COPD by solid-phase enzyme-linked immunosorbent assay. 70 healthy individuals were normal control group (referred to as control group). Results The positive rate of IgM antibody (36.5%, 46/126) and IgM and / or IgG (32.8%, 42/126) in COPD group were significantly higher than those in lung cancer group (21.8%, 28/128 and 23.1% (P <0.005). The positive rate of IgM in lung cancer group was significantly higher than that in control group (P <0.005) The positive number of IgM and / or IgG was 74 and the total infection rate was 22.8% (74/324). Conclusion Both lung cancer and COPD patients are predominantly Cpn-infected, and Cpn infection is mainly acute infection. Cpn may be the main pathogen of acute exacerbation of COPD and lung cancer complicated with pulmonary infection.