论文部分内容阅读
目的探讨健脾益气化瘀法联合硫酸羟氯喹治疗干燥综合征临床疗效。方法将60例干燥综合征患者随机分为2组:对照组口服硫酸羟氯喹0.2g 2次/日,治疗组口服健脾益气化瘀自拟方联合硫酸羟氯喹0.2g 2次/日治疗。连续治疗12周为1个疗程,比较2组患者临床疗效及安全性。结果治疗后,治疗组口干、眼干、关节痛症状积分,RF,ESR,hs-CRP,Ig G,眼滤纸试验水平与治疗前比较均明显改善(P<0.05);且治疗组的各项指标改善均优于对照组,比较有统计学意义(P<0.05)。治疗组总有效率(89.7%)明显高于对照组总效率(73.3%),(P<0.05);两组不良反应比较无显著性差异(P>0.05)。结论健脾益气化瘀法联合硫酸羟氯喹治疗干燥综合征能有效改善口干、眼干、关节痛等临床症状,降低Ig G、RF及炎症指标,缓解病情,疗效优于单纯西医治疗。
Objective To investigate the clinical effects of invigorating the spleen, reinforcing qi and removing blood stasis method and hydroxychloroquine sulfate in the treatment of Sjogren’s syndrome. Methods Sixty patients with Sjogren’s syndrome were randomly divided into two groups: the control group was orally given 0.2 g hydroxychloroquine 2 times a day, and the treatment group was treated with qi and blood stasis spleen qi and blood stasis combined with 0.2 g hydroxychloroquine twice daily . Continuous treatment for 12 weeks for a course of treatment, the clinical efficacy and safety of two groups were compared. Results After treatment, the scores of dry mouth, dry eye, joint pain symptom, RF, ESR, hs-CRP, Ig G and eye filter paper were significantly improved in treatment group compared with those before treatment (P <0.05) The improvement of indicators were better than the control group, with statistical significance (P <0.05). The total effective rate (89.7%) in the treatment group was significantly higher than that in the control group (73.3%) (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion The treatment of Sjogren’s Syndrome with Jianpi Yiqi Huayu Decoction combined with hydroxychloroquine sulfate can effectively improve the clinical symptoms such as dry mouth, dry eye and arthralgia, reduce Ig G, RF and inflammation index, alleviate the disease and the curative effect is better than that of western medicine alone.