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OBJECTIVE:To explore the anti-aging effects of mild-warming moxibustion on Bcl-2 and PKC expression in peripheral blood and general symptoms in elderly people.METHODS:A total of 61 elderly people and 30 non-elderly people were enrolled.The total effective rate of mild-warming moxibustion was assessed by symptom scores,and Bcl-2 and PKC expression in peripheral blood was detected by flow cytometry.RESULTS:The total effective rate in the mild-warming moxibustion group was significantly higher than in the blank control group (P<0.01).Bcl-2 and PKC expression rates in peripheral blood in the blank control group were lower than in the normal control group (P<0.01), but higher after mild-warming moxibustion (P<0.01).CONCLUSION:The anti-aging effects of mild-warming moxibustion may be due to increased Bcl-2 and PKC expression in peripheral blood in aged people.