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为探讨谷胱甘肽－Ｓ－转移酶Ｍ１基因５＇端非编码区ＣＧＧ三核苷酸重复序列长度多态与肝癌遗传易感性的关系，采用ＰＣＲ－ＰＡＵＧＥ－ＤＮＡ银染方法，对６５例肝癌患者和１０６例健康对照的研究表明，病例组和对照组ＣＧＧ拷贝数小于６者，分别占４９．２３％和７．５５％，两组差异显著（Ｐ＜０．０００１）。ＯＲ值为１１．８８，ＥＦ值为０．４５０９．提示ＣＧＧ拷贝数小于６者，患肝癌的危险性增加１０．８８倍，由ＣＧＧ拷贝数小于６所致的肝癌病例占人群中全部肝癌病例的４５．０９％。
To investigate the relationship between the length polymorphism of CGG trinucleotide repeats in the 5’-untranslated region of glutathione-S-transferase M1 gene and genetic susceptibility to hepatocellular carcinoma, PCR-PAUGE-DNA silver staining method was used in 65 cases. The study of liver cancer patients and 106 healthy controls showed that the CGG copy number was less than 6 in the case group and the control group, accounting for 49.23% and 7.55%, respectively, with significant differences between the two groups (P<0.0001). The OR value is 11.88 and the EF value is 0.4509. If the CGG copy number is less than 6, the risk of developing liver cancer increases 10.88 times. The liver cancer cases caused by CGG copy number less than 6 account for 45.09% of all liver cancer cases in the population.