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目的探讨碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)对多孔钽颗粒修复犬颌骨缺损过程中的促进效果。方法 Beagle犬6只,建立下颌骨缺损模型共计36个,单侧3个骨缺损分别为多孔钽颗粒修复组(实验组A)、bFGF+多孔钽颗粒修复组(实验组B)、无干预组(对照组)。术后4、8、12周各处死2只犬,行大体、X线、组织学观察及新生骨面积统计分析。结果 X线片示实验组与周围骨质结合良好,对照组12周后仍可见低密度骨缺损区域。甲苯胺蓝染色示术后8周及12周实验组B骨连续性及成熟度优于实验组A。术后4周实验组B新生骨形成面积明显大于实验组A(P<0.05),而8周末实验组A明显大于实验组B(P<0.05)。结论 b FGF可增强多孔钽颗粒的骨修复能力。
Objective To investigate the promotion effect of basic fibroblast growth factor (bFGF) on the restoration of canine jaw defects by porous tantalum particles. Methods Six Beagle dogs were established, including 36 mandibular defects models. Three unilateral bone defects were repaired with porous tantalum particles (experimental group A), bFGF + porous tantalum particles modified group (experimental group B), without intervention group Control group). At the 4th, 8th and 12th week after operation, 2 dogs were sacrificed, and gross, X-ray, histological observation and statistical analysis of new bone area were performed. Results The X-ray showed that the experimental group had a good combination with the surrounding bone. In the control group, the low-density bone defect area was still seen after 12 weeks. Toluidine blue staining showed that the continuity and maturity of B bone in experimental group were better than that of experimental group A at 8 and 12 weeks after operation. At 4 weeks after operation, the area of bone formation in experimental group B was significantly larger than that in experimental group A (P <0.05), while the experimental group A at 8 weeks was significantly larger than that of experimental group B (P <0.05). Conclusion b FGF can enhance the bone repair ability of porous tantalum particles.