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卵泡成熟及排卵是促性腺激素与雌激素协同调节的结果。在卵巢局部,二者协同促进排卵前卵泡的成熟,卵泡分泌的雌激素还反馈作用于下丘脑一垂体轴,并最终触发排卵前的LH峰。基于目前对人卵巢中雌激素生物合成的主要卵泡内定位(即在颗粒细胞、被膜细胞或二者)尚无统一看法,本文拟确定颗粒细胞的芳香化酶活性与卵泡液中雌激素的水平以及芳香化酶底质之间是否存在相关性,并比较了从分泌雌激素的卵泡中得到的被膜细胞和颗粒细胞的芳香化酶活性。从11例内分泌正常的年轻妇女,经单侧卵巢切除术得到完整的卵巢。将卵巢立即放入冰冷的培养
Follicular maturation and ovulation are the result of coordinated regulation of gonadotropins and estrogen. In the ovary part, the two synergistic to promote ovulation follicle maturation, follicular secretion of estrogen feedback role in the hypothalamic-pituitary axis, and ultimately trigger ovulation LH peak. Based on the current lack of a uniform view of the localization of the major follicles in estrogen biosynthesis in human ovaries (ie, granulosa cells, enveloping cells, or both), we intend to determine the level of estrogen in granulosa cells And the aromatase substrate, and compared the aromatase activity of the enveloping cells and granulosa cells obtained from the estrogen-secreting follicles. From 11 cases of endocrine normal young women, unilateral ovariectomy to obtain a complete ovary. The ovary immediately into the cold culture