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目的对血清胱抑素C检测在糖尿病肾病中的临床诊断价值进行探讨和研究。方法随机选取2009年12月至2011年12月于我院接受诊治的76例糖尿病患者,Ⅰ组36例为糖尿病无肾损伤患者,Ⅱ组40例为糖尿病肾病患者,另选取32例健康志愿者作为对照组,采取免疫比浊法对所选病例的血清胱抑素C的含量进行检测,并对各组病例的尿素氮、血肌酐、糖化血红蛋白和尿微量清蛋白排泄率等指标进行检测,分析其相关性。结果通过检测发现Ⅰ组患者的血清胱抑素C含量为(1.22±0.24)mg/L,Ⅱ组患者的为(3.62±0.84)mg/L,对照组的为(0.91±0.21)mg/L,糖尿病肾病患者的血清胱抑素含量同对照组、糖尿病无肾病患者比较差异具有统计学意义(P<0.05);Ⅱ组患者的尿素氮、血肌酐、糖化血红蛋白和尿微量清蛋白排泄率等指标与对照组比较差异有统计学意义(P<0.05)。结论血清胱抑素C含量与糖尿病肾病的关系密切,可以作为临床诊断该病的重要指标。
Objective To investigate the clinical value of serum cystatin C in diabetic nephropathy. Methods A total of 76 patients with diabetes mellitus who were diagnosed and treated in our hospital from December 2009 to December 2011 were randomly selected. Group Ⅰ 36 patients with diabetes without renal injury, group Ⅱ 40 patients with diabetic nephropathy and another 32 healthy volunteers As the control group, the turbidimetric method was used to detect the level of serum cystatin C in the selected cases, and the urinary nitrogen, serum creatinine, glycosylated hemoglobin and urinary albumin excretion rate were detected in each group, Analyze its relevance. Results The level of serum cystatin C was (1.22 ± 0.24) mg / L in group Ⅰ, (3.62 ± 0.84) mg / L in group Ⅱ and (0.91 ± 0.21) mg / L in control group , Serum cystatin levels in patients with diabetic nephropathy compared with the control group, diabetic patients without nephropathy was statistically significant (P <0.05); in patients with urea nitrogen, serum creatinine, glycosylated hemoglobin and urinary albumin excretion rate There was significant difference between the index and the control group (P <0.05). Conclusions Serum levels of cystatin C are closely related to diabetic nephropathy and may be used as an important index for clinical diagnosis of the disease.