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目的观察根治性手术和姑息性手术对晚期胃癌患者血清糖类抗原72-4(CA72-4)和血管内皮生长因子(VEGF)的影响和意义。方法回顾分析39例手术治疗的晚期胃癌患者,27例采用根治性手术治疗,12例采用姑息性手术治疗,术后常规化疗,随访6月,测定患者治疗前后血清CA72-4和VEGF。结果两组患者治疗前血清CA72-4和VEGF无明显差异(P>0.05),手术6月随访,患者血清CA72-4和VEGF均明显下降(P<0.01),并且观察组降低更明显(P<0.01)。术后随访复发11例,与未复发患者比较血清CA72-4和VEGF明显升高(P<0.01)。结论血清CA72-4和VEGF对胃癌晚期患者术后复发有明确的预测价值,采用根治性手术治疗晚期胃癌效果更明显。
Objective To observe the effect and significance of radical surgery and palliative surgery on serum carbohydrate antigen 72-4 (CA72-4) and vascular endothelial growth factor (VEGF) in patients with advanced gastric cancer. Methods Retrospective analysis of 39 cases of advanced gastric cancer surgery patients, 27 cases of radical surgery, 12 cases of palliative surgery, conventional chemotherapy, followed up for 6 months, measured before and after treatment of patients with serum CA72-4 and VEGF. Results There was no significant difference in the serum levels of CA72-4 and VEGF between the two groups before treatment (P> 0.05). The levels of serum CA72-4 and VEGF were significantly decreased at 6-month follow-up (P <0.01) <0.01). Eleven patients were followed up for recurrence. Serum CA72-4 and VEGF were significantly higher than those without recurrence (P <0.01). Conclusions Serum CA72-4 and VEGF have definite predictive value for postoperative recurrence in patients with advanced gastric cancer, and radical surgery for advanced gastric cancer is more effective.