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大鼠静注常咯啉再注射乌头硷,或同时用常咯啉和乌头硷,明显推迟乌头硷引起的心律紊乱。先静注乌头硷出现心律失常后,再注射常咯啉,抗心律失常作用较弱。剪断二侧迷走神经,或静注六烃季铵,都不影响常咯啉抗静注乌头硷所致心律失常的疗效。从静脉恒速注射乌头硷,记录室性早搏、室性心动过速和心室颤动阈值。预先静脉注射常咯啉明显提高这三种阈值。利血平化加常咯啉组,这些阀值也比对照组明显提高,与常咯啉组相比,仅显著提高心室颤动阈值。脑室内注射常咯啉后,再脑室内注射乌头硷,明显推迟心律失常出现时间。常咯啉对大鼠坐骨神经的局麻作用甚微,这与利多卡因有明显不同。
Rats intravenous injection of regular furosemide aconitine, or both with regular furosemide and aconitine, significantly delayed aconitine-induced heart rhythm disorders. The first intravenous injection of aconitum arrhythmia, then injection of regular pyrroline, anti-arrhythmic effect is weak. Clipping the vagus nerve on both sides, or intravenous hexachlorocyclobutel, does not affect the regular intravenous aconitine aconitine induced arrhythmia effect. Aconitine was injected intravenously at a constant rate and ventricular premature beats, ventricular tachycardia and ventricular fibrillation threshold were recorded. Pre-intravenous injection of morpholine significantly increased these three thresholds. Reserpine plus protoporphyrin group, these thresholds also significantly higher than the control group, compared with the regular pyrroline group, only significantly increased ventricular fibrillation threshold. Intracerebroventricular intraventricular injection of pyrroline, intraventricular injection of aconitine, significantly delayed the onset of arrhythmia. Cyanotropin has little effect on local anesthesia in rat sciatic nerve, which is obviously different from that of lidocaine.