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目的:探讨P16、CyclinD1基因在维吾尔族葡萄胎发生方面的意义。方法:用免疫组化二步法,对46例葡萄胎首次清宫标本和20例早孕正常绒毛组织中P16和CyclinD1进行检测。结果:在早孕绒毛组织中CyclinD1表达全部阴性,而P16阳性率为80.0%。在葡萄胎组中P16、CyclinD1表达阳性率分别60.9%,23.9%。在非恶变葡萄胎、以后发生恶变的葡萄胎中P16表达呈下降趋势,CyclinD1表达呈上升趋势。结论:P16表达缺失、Cy-clinD1过表达可能在葡萄胎恶性转化中起重要作用。检测葡萄胎首次清宫标本P16及CyclinD1表达可能在判断葡萄胎预后方面具有重要意义。
Objective: To investigate the significance of P16 and CyclinD1 gene in the occurrence of Uygur mole. Methods: The immunohistochemical two-step method was used to detect the expression of P16 and CyclinD1 in 46 cases of first trimester of mole and 20 cases of normal villi in early pregnancy. Results: The expression of CyclinD1 was negative in the first trimester, while the positive rate of P16 was 80.0%. The positive rates of P16 and CyclinD1 in hydatidiform mole were 60.9% and 23.9% respectively. In non-malignant hydatidiform mole, the subsequent occurrence of malignant hydatidiform mole in P16 expression showed a downward trend, CyclinD1 expression showed an upward trend. Conclusion: The lack of P16 expression and Cy-clinD1 overexpression may play an important role in the malignant transformation of hydatidiform mole. Detection of hydatidiform mole for the first time in patients with P16 and CyclinD1 expression may be important in determining the prognosis of hydatidiform mole.