论文部分内容阅读
目的 了解1 86 铼 碘化油 (1 86 Re Lipiodol,RL)进入人体后是否能在肝癌组织中浓聚 ,对靶组织有无杀伤作用 ,对周围组织及全身脏器毒性如何。 方法 通过理化方法将核素1 86 铼包在碘化油中 ,制成RL。选原发性肝癌 (primarylivercancer,PLC)患者 1 4例 ,经Seldinger′s法插管到肝动脉 ,根据肿块大小分别注入RL 1 0～ 2 0ml(含1 86 铼 1 1 1 0～ 2 2 2 0MBq) ,通过ECT了解RL的体内分布 ,根据甲胎蛋白 (AFP)含量的消长及肿块缩小情况 ,判断其疗效。 结果 RL进入人体后 ,几乎全部浓聚于肝癌组织中 ,靶 /非靶 (N/NT)值达 (1 0～ 1 4 ) :1 ;对机体的毒性反应极轻 ;所有患者的AFP进行性降低 ,其中 1例转阴 ;肿瘤均不同程度缩小 ,其中PR占 78%。 结论 RL中的核素1 86 铼随碘化油的微小油滴“选择性”地分布在肝癌组织中 ,起到了核素内照射的作用
Objective To investigate whether 1 86 Re Lipiodol (RL) enters the human body to accumulate in liver cancer tissue, whether it has any killing effect on target tissues or not, and whether it has toxic effects on the surrounding tissues and whole organs. Methods The physical and chemical methods of the radionuclide 1 86 rhenium in iodized oil, made of RL. Twenty-four patients with primary liver cancer (PLC) were selected and intubated to the hepatic artery via Seldinger’s method. The tumors were infused with RL 10-20 ml (containing 1 86 rhenium, 1 1 1 0-2 2 2 0MBq) to understand the distribution of RL in vivo by ECT. According to the increase and decrease of AFP content and the shrinkage of the tumor, the curative effect was evaluated. Results RL entered the human body and almost all concentrated in the liver cancer tissues. The target / non-target (N / NT) value was (1 0 ~ 1 4): 1. Toxicity to the body was extremely low. Decreased, of which 1 case turned negative; tumors were reduced to varying degrees, of which PR accounted for 78%. Conclusion The radionuclide 1 86 rhenium in RL is selectively “selectively” distributed in hepatocellular carcinoma with small oil droplets of iodized oil and plays a role of radionuclide irradiation