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将24只SD大鼠分为4组,三甲基氯化锡(TMT)组分别给予4.64 mg/kg、10 mg/kg和21.5 mg/kg TMT染毒,对照组给予生理盐水,染毒后24 h测定肠道推进功能和Na+-K+-ATPase活力;另将24只大鼠分为4组,TMT组给予10mg/kg染毒,对照组给予生理盐水,分别在3 d和6 d测定肠道推进功能和Na+-K+-ATPase活力。结果显示,大鼠小肠不同部位的Na+-K+-ATPase活力不同。经TMT染毒后肠道推进率较对照组明显降低(P<0.01),中高剂量染毒组的肠道Na+-K+-ATPase活力明显降低(P<0.01)。10 mg/kg TMT染毒大鼠3 d和6 d肠道Na+-K+-ATPase活力亦明显下降(P<0.05)。提示TMT染毒可能会抑制小肠推进功能,推进率的下降可能与肠道Na+-K+-ATPase活力抑制有关。
Twenty-four Sprague-Dawley rats were divided into four groups. The rats in TMT group were treated with TMT at doses of 4.64 mg / kg, 10 mg / kg and 21.5 mg / kg respectively. The control group was given normal saline, 24 h, the intestinal propulsive function and Na + -K + -ATPase activity were measured. Twenty-four rats were divided into four groups. The TMT group was given 10 mg / kg and the control group was given saline. Road propulsion function and Na + -K + -ATPase activity. The results showed that different parts of the small intestine Na + -K + -ATPase activity is different. The intestinal propulsion rate in TMT group was significantly lower than that in control group (P <0.01). The intestinal Na + -K + -ATPase activity in medium and high dose groups was significantly decreased (P <0.01). The activities of Na + -K + -ATPase in the intestinal tract of rats exposed to 10 mg / kg TMT for 3 d and 6 d were also significantly decreased (P <0.05). Tip TMT toxicity may inhibit intestinal prolapse function, the decline in the rate of prophylaxis may be related to inhibition of intestinal Na + -K + -ATPase activity.