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砜类药物治疗麻风已有40年的历史,疗效是肯定的。但其疗程长,且由于氨苯砜单一疗法所引起的耐药菌株的出现以及持续残存活菌所致麻风病情的复发,不利于麻风控制规划的实现。随着对麻风杆菌有杀菌作用的其它抗麻风药物的应用,目前已分离出了对利福平(RFP)、乙硫异烟胺(ETH)和氯苯吩嗪(B663)耐药的麻风菌株。根据结核病的经验,联合化疗可能在一定程度上有助
Sulfone drug treatment of leprosy has 40 years of history, the effect is yes. However, its long course of treatment and the emergence of drug-resistant strains caused by monotherapy with dapsone and the recurrence of leprosy resulting from persistent viable bacteria are not conducive to the implementation of the leprosy control program. Leprosy strains resistant to rifampicin (RFP), ethionamide (ETH) and cloprofen (B663) have now been isolated with the use of other anti-leprosy drugs that have bactericidal effects against M. leprae . According to the experience of tuberculosis, combined chemotherapy may be to some extent help