Dear Editor,rnThe COVID-19 pandemic caused by the SARS-CoV-2 virus has caused a significant public health crisis worldwide.Recent studies show that excessive inflammatory response is critical for SARS-CoV-2 pathogenesis and COVID-19 severity,1 which can lead to acute lung injury(ALI)and acute respiratory distress syndrome(ARDS).2 One major factor for acute inflammation in SARS-CoV-2 infection is the inflammatory macrophages,which has been considered important for the production of large amounts of proinflammatory cytokines.3 Autopsy identified an intense infiltra-tion of macrophages in the lung tissues of fatal COVID-19 patients.4 Furthermore,single-cell RNA sequencing(scRNA-seq)showed a higher proportion of macrophages presenting in bronchoalveolar lavage fluid(BALF)of severe COVID-19 patients.5 Consistent with studies of SARS-CoV-2,infiltration and accumula-tion of macrophages in the lung were also found in other coronavirus diseases.6 Depletion of macrophages protected mice from lethal SARS-CoV infection,highlighting the important roles of macrophages in coronavirus-induced symptoms.7 Therefore,targeting macrophages to regulate hyperinflammation in SARS-CoV-2 infection could be an effective strategy to treat COVID-19 patients.