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本文应用活体粗针穿刺和PAP免疫组化技术对17例初发GD、7例治疗后GD、13例AT、5例正常甲状腺及某些肿瘤甲状腺组织中T_3、T_4的定位及其相对含量进行了研究。T_3、T_4在甲状腺组织中的定位分布相似,主要位于滤泡腔胶质中,功能亢进者所有胶质均呈浓染着色,且部分滤泡细胞近滤泡腔缘的胞浆中也出现较弱的染色反应。GD未治疗者甲状腺组织内T_3、T_4相对含量显著增加,经治疗后明显下降。AT病变中的嗜酸性变细胞基本失去了制造T_3、T_4的功能。
In this study, the localization and relative content of T_3 and T_4 in 17 cases of primary GD, 7 cases of post-treatment GD, 13 cases of AT, 5 cases of normal thyroid and some tumor thyroid tissues were examined by live needle biopsy and PAP immunohistochemistry Study. The distribution of T_3 and T_4 in thyroid tissue were similar, mainly in the glial cavity of the follicular cavity. All the glia of the hyperactive hyperthyroidism were strongly stained and the cytoplasm of some follicular cells near the follicular margin also appeared more Weak staining reaction. The relative content of T_3 and T_4 in thyroid tissue of GD untreated group increased significantly, but decreased obviously after treatment. AT lesions of eosinophilic alzheimers basically lost the manufacture of T_3, T_4 function.