卵巢癌是一种非常严重的疾病,常确诊晚预后差。多年来,多认为它无内分泌作用。已发表的资料表明,非内分泌性卵巢肿瘤也产生小量孕酮(P)、20α-羟-孕酮、雄烯二酮(A)、睾丸酮和雌二醇。其血浆类固醇浓度与肿瘤体积呈正相关。化疗期间,肿瘤体积缩小的患者血浆P和A的水平均降低。本文旨在观察卵巢癌复发前激素的改变。作者们对13例绝经后患恶性卵巢肿瘤而无其他恶性及内分泌疾病的妇女进行血浆P和A浓度的研究。其组织学分型为Ⅰ_c(5例),Ⅲ_c(1例),和Ⅴ(7例)。按FIGO标准为Ⅲ期(7例),Ⅳ期(6例)。所有患者均接受过化疗,其中2例取血前接受过减瘤手术治疗。从确诊到瘤复发平均8.4个月,从确诊到死亡平均12.8个月。对照组A是20例无恶性和内科病或未用任何药 Ovarian cancer is a very serious disease, often poor prognosis late diagnosis. Over the years, many think it has no endocrine role. Published data indicate that non-endocrine ovarian tumors also produce small amounts of progesterone (P), 20α-hydroxy-progesterone, androstenedione (A), testosterone and estradiol. The plasma steroid concentration and tumor volume was positively correlated. Plasma levels of P and A decreased in patients with tumor volume reduction during chemotherapy. This article aims to observe the changes of hormones before ovarian cancer recurrence. The authors studied the plasma concentrations of P and A in 13 women with postmenopausal malignant ovarian tumors and no other malignant and endocrine disorders. The histological classification of Ⅰ_c (5 cases), Ⅲ_c (1 case), and Ⅴ (7 cases). According to FIGO standard for the three (7 cases), Ⅳ (6 cases). All patients received chemotherapy, of which 2 received blood-letting surgery prior to taking the blood. From the diagnosis to tumor recurrence average 8.4 months, from the diagnosis to the death of an average of 12.8 months. Control A was 20 without malignancy and medical disease or without any medication