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维生素B_1的原料及其制剂的含量测定,中国药典1977年版采用重量法,但该法操作繁琐费时。为此,我们根据文献报道(南京药学院主编:药物分析,159页,人民卫生出版社,1981),采用分光光度法测定维生素B_1原料、针剂及片剂的含量并与药典法进行了比较,两法结果基本一致,但本法较简便、快速。 1.维生素B_1原料含量测定法:取本品约50mg,精密称定,加水50ml溶解后,置100ml量瓶中,加水稀释至刻度,摇匀,精密量取2ml,置另一100ml量瓶中,加盐酸溶液(1→25)2 m1,加水稀释至刻度,摇匀。照分光光度法(中国药典1977年版,二部,附录21页)在246±1
Determination of the content of raw materials and preparation of vitamin B_1, Chinese Pharmacopoeia 1977 edition using the weight method, but the method is cumbersome and time-consuming operation. To this end, we report the literature (Nanjing Pharmaceutical College editor: Drug Analysis, 159 pages, People’s Health Publishing House, 1981), the determination of vitamin B 1 raw materials, injections and tablets content and compared with the pharmacopoeia, The results of the two laws are basically the same, but this law is simpler and faster. 1. Vitamin B_1 raw material determination method: Take this product about 50mg, accurately weighed, add water 50ml dissolved, set 100ml flask, add water diluted to the mark, shake, the precise amount of 2ml, set another 100ml flask , Add hydrochloric acid solution (1 → 25) 2ml, dilute with water to the mark, shake well. According to spectrophotometry (Chinese Pharmacopoeia 1977 edition, two, Appendix 21) at 246 ± 1