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自噬是细胞的一个重要生物学功能。细胞通过对自噬底物的识别、自噬囊泡的形成,再经过与溶酶体的融合,清除老化细胞器以及降解长周期蛋白和异常积聚蛋白。因此,自噬在蛋白质的代谢、细胞器更新以及组织发育中有着重要作用,其功能调控直接参与了机体对细胞稳态的维持
Autophagy is an important biological function of cells. Cells recognize autophagy substrates, form autophagic vesicles, and fuse with lysosomes to clear aging organelles and degrade long-term and abnormally-aggregated proteins. Therefore, autophagy plays an important role in protein metabolism, organelle renewal and tissue development. Its functional regulation is directly involved in the maintenance of cell homeostasis