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肺支原体（M.pulmois）经鼻一次性人工感染成年普通青紫兰兔和清洁级昆明小鼠，105CFU／只，然后饲喂于20±2℃，相对湿度60±10％的开放环境中，隔七天取鼻咽、气管拭子、肺及血样，经分离培养法追踪感染菌在兔、鼠呼吸系统的分布，用间接ELISA法检测相应感染期内血液中抗体IgG的变化情况结果表明，开放系统中MP经一鼻次性人工感染后普通级青紫兰兔肺泡周围分布最多，同时在鼻腔、咽、气管各段均有，且在感染第十四天，部分兔死亡，随后加剧，在21天内全部感染兔死亡，血液在感染第7－14天出现，并达最高值。清洁级昆明小鼠对MP不敏感，在感染49天中仅有1只死亡。同时血中抗体IgG在感染第7天达最高，随后逐渐下降，28天后几乎用间接ELISA法测不出来。小鼠感染0－14天内，M.Pul均可从鼻腔、咽、气管、肺分得，随后仅能从鼻咽部和气管分得。
Mycoplasma hominis (M.pulmois) was infested with nasal common adult cyan rabbits and clean-grade Kunming mice at a dose of 105 CFU / mouse and then fed to an open environment at 20 ± 2 ° C. and relative humidity of 60 ± 10% Nasopharyngeal, tracheal swabs, lungs and blood samples were taken on the 7th day. The distribution of respiratory bacteria in the rabbits and mice was tracked by isolation culture method. The changes of IgG in the blood during the corresponding infection period were detected by indirect ELISA. The results showed that the open system In the MP after a nasal infection, the average grade Cyanosis rabbits alveolar distribution around the most, while in the nasal cavity, pharynx and trachea are all, and in the fourteenth day of infection, some rabbits died, then aggravated, within 21 days All infected rabbits died, blood appeared on day 7-14 of infection and reached the highest value. Cleaner Kunming mice are not sensitive to MP, with only 1 death 49 days after infection. At the same time, the antibody IgG in the blood reached the highest level on the 7th day of infection, then gradually decreased. After almost 28 days, the indirect ELISA was not available. Mouse infection 0-14 days, M.Pul can be obtained from the nasal cavity, pharynx, trachea, lung, and then only from the nasopharynx and trachea divided.