目的探讨新生儿B族链球菌(GBS)败血症的临床特点。方法收集2008年6月至2011年4月本院新生儿重症监护病房住院的GBS败血症新生儿资料,回顾性分析GBS败血症患儿的围产期因素、临床表现、实验室检查、治疗与转归。结果 GBS败血症16例,占住院患儿的2.53‰,其中早发型败血症12例,迟发型败血症4例。本院出生7例,占本院出生新生儿的0.43‰。早发型病例以呼吸系统症状为主,生后24 h内发病,迟发型病例以高热为首发症状,均合并化脓性脑膜炎。GBS败血症患儿血WBC明显低于正常,降钙素原反应灵敏,C反应蛋白反应相对滞后。16例血GBS阳性标本均对万古霉素和青霉素敏感,青霉素联合三代头孢或美罗培南治疗有效。结论新生儿GBS败血症临床症状典型、病情凶险,应重视围产期高危因素和早期临床表现,尽早行病原学检测,合理足疗程使用敏感抗生素治疗,有效降低病死率和致残率。 Objective To investigate the clinical features of neonatal B streptococcal (GBS) sepsis. Methods The neonatal data of GBS sepsis hospitalized in neonatal intensive care unit in our hospital from June 2008 to April 2011 were collected. The perinatal factors, clinical manifestations, laboratory tests, treatment and outcome of GBS sepsis children were retrospectively analyzed . Results Sixteen cases of GBS sepsis accounted for 2.53% of the hospitalized children, including 12 cases of early-onset sepsis and 4 cases of delayed-type sepsis. The hospital was born in 7 cases, accounting for 0.43 ‰ of newborns born in our hospital. Early onset cases of respiratory symptoms, the incidence within 24 h after birth, delayed onset cases with high fever as the first symptom, were associated with purulent meningitis. GBS sepsis in children with blood WBC was significantly lower than normal, procalcitonin response sensitive, C-reactive protein response lags behind. 16 cases of blood GBS positive specimens were susceptible to vancomycin and penicillin, penicillin combined with third generation cephalosporins or meropenem treatment is effective. Conclusion The clinical symptoms of neonatal GBS sepsis are typical and dangerous in the future. High risk factors and early clinical manifestations of perinatal period should be paid attention to. Pathogenic tests should be conducted as soon as possible and sensitive antibiotics should be used for a reasonable duration of treatment to reduce mortality and morbidity.