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目的观察老年男性T2DM患者血清硫酸脱氢表雄酮(DHEA-S)含量的变化,初步探讨其临床意义。方法放免法测定82例老年男性T2DM患者(DM组)血清DHEA-S,并与35名男性健康老年人(NC组)比较。结果 DM组血清DHEA-S显著降低,合并微血管病变组显著低于无微血管病变组,肥胖者明显低于体重正常者。多元Logistic回归分析结果显示,与血清DHEA-S降低有独立相关性的因素分别是增龄、BMI增加、微血管并发症及FPG、Ins、C P、ApoB、TG增加。结论老年男性T2DM患者血清DHEA-S降低,并与DM危险因素,如机体老化、肥胖、微血管病变、FPG控制差、高胰岛素血症、C-P高值、Apo B高值及高TG血症密切相关。
Objective To investigate the changes of serum DHEA-S in elderly men with T2DM and to explore the clinical significance. Methods Serum DHEA-S in 82 elderly men with T2DM (DM group) was determined by radioimmunoassay and compared with 35 healthy male controls (NC group). Results The serum DHEA-S in DM group was significantly lower than that in non-MCAO group and obese group was significantly lower than that of normal weight group. Multivariate logistic regression analysis showed that the independent factors associated with the decrease of serum DHEA-S were age, BMI, microvascular complications and FPG, Ins, C P, ApoB and TG respectively. Conclusions The serum level of DHEA-S in elderly men with T2DM is decreased and is closely related to the risk factors of DM, such as body aging, obesity, microangiopathy, poor control of FPG, hyperinsulinemia, high CP, high Apo B and high TG .