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目的·探讨肿瘤复发与p53不同位点突变体之间的相关性。方法·癌症基因组计划(TCGA)和纪念斯隆-凯特琳癌症中心(MSKCC)中的肿瘤患者按照携带的p53突变体类型进行分类,并比较肿瘤手术治疗后复发时间的差异。结果·位于第248和282氨基酸位点的p53错义突变体与肿瘤复发时间的缩短显著相关(P<0.05,HR>2)。虽然位于175、245和273位点的热点突变体具有增加的风险比,但差异并无统计学意义。当相同类别的突变被归为一组时,热点突变体(而不是所有错义突变体)与更短的复发时间相关。移码突变体与无义突变体具有基本相当的肿瘤复发时间。结论·并非所有p53热点突变体都与肿瘤复发时间的缩短相关,p53的各种热点突变应该作为不同的肿瘤标记物加以区别对待。
Objective To explore the correlation between tumor recurrence and p53 site mutation. Methods Tumor patients in the Cancer Genome Project (TCGA) and Memorial Sloan-Kettering Cancer Center (MSKCC) were categorized according to the type of p53 mutation carried and compared with the time of recurrence after tumor surgery. Results · The p53 missense mutants at amino acid positions 248 and 282 were significantly associated with the shortened tumor recurrence (P <0.05, HR> 2). Although hotspot mutants at positions 175, 245 and 273 had an increased risk ratio, the difference was not statistically significant. Hot spot mutants (but not all missense mutants) correlate with shorter recurrence times when the same category of mutations are grouped together. Frameshift mutants have roughly comparable tumor recurrence times as nonsense mutants. CONCLUSIONS: Not all p53 hotspot mutants are associated with a shortened time to tumor recurrence, and various hotspot mutations of p53 should be treated differently as different tumor markers.