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目的探讨缺血修饰白蛋白(IMA)、肌钙蛋白Ⅰ(cTnI)、氨基末端B型利钠肽前体(NT-proBNP)和高敏C反应蛋白(hs-CRP)水平对急性冠脉综合征(ACS)的诊断价值。方法将诊断为ACS的43例患者与60例健康对照者进行IMA、cTnI、NT-proBNP和hs-CRP的检测,统计IMA、cTnI单独及联合检测诊断ACS的灵敏度和特异性。结果 43例ACS组患者IMA、cTnI、NT-proBNP和hs-CRP结果分别为(82.0±18.5)U/L、(1.54±1.96)ng/ml、(1 040±915)ng/L、(16.1±9.4)mg/L,与对照组比较有较大差异,IMA、cTnI单独及联合检测诊断ACS的灵敏度分别为79.5%、55.9%、91.1%,特异性分别为81.8%、97.7%、84.8%。结论 IMA、cTnI可用于ACS的早期诊断,NT-proBNP、hs-CRP用于判断ACS的严重程度,这四项指标对ACS的诊断和治疗有比较大的临床意义。
Objective To investigate the effect of ischemic-modified albumin (IMA), cTnI, NT-proBNP and hs-CRP on acute coronary syndrome (ACS) diagnostic value. Methods 43 patients diagnosed with ACS and 60 healthy controls were examined for IMA, cTnI, NT-proBNP and hs-CRP, and the diagnostic sensitivity and specificity of IMA and cTnI alone and in combination were detected. Results The results of IMA, cTnI, NT-proBNP and hs-CRP in 43 ACS patients were (82.0 ± 18.5) U / L, (1.54 ± 1.96) ng / ± 9.4) mg / L, which were significantly different from the control group. The diagnostic sensitivity of IMA and cTnI alone and in combination were 79.5%, 55.9% and 91.1%, respectively, and the specificity were 81.8%, 97.7% and 84.8% . Conclusions IMA and cTnI can be used in the early diagnosis of ACS. NT-proBNP and hs-CRP can be used to judge the severity of ACS. These four indexes are of great clinical significance for the diagnosis and treatment of ACS.