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目的研究患者血清高密度脂蛋白(HDL-C)与超敏C-反应蛋白(hs-CRP)水平对冠心病发病及其预后的影响。方法对112例拟诊为冠心病患者行冠状动脉造影并根据结果分为冠心病组与非冠心病组,以上患者均采取静脉血测定血清HDL-C及hs-CRP水平,应用统计学方法评定其与冠心病发病及预后的相关性。结果冠心病组患者血清HDL-C水平低于非冠心病组(P<0.01),冠心病组患者血清hs-CRP水平高于非冠心病组(P<0.05);HDL-C和hs-CRP均为冠心病的独立影响因素(P<0.05);HDL-C与冠心病患者1a内心脏事件的发生独立相关(P<0.05)。结论患者血清HDL-C和hs-CRP水平均是冠心病发病的独立影响因素,HDL-C水平与冠心病患者预后密切相关。
Objective To study the effect of serum HDL-C and hs-CRP on the incidence and prognosis of coronary heart disease. Methods One hundred and twelve patients diagnosed as coronary heart disease underwent coronary angiography and divided into coronary heart disease group and non-coronary heart disease group according to the results. Serum HDL-C and hs-CRP levels were measured by venous blood in the above patients, and were statistically assessed Its correlation with the incidence and prognosis of coronary heart disease. Results The serum levels of HDL-C in CHD patients were lower than those in non-CHD patients (P <0.01). The serum levels of hs-CRP in CHD patients were higher than those in non-CHD patients (P <0.05) (P <0.05). HDL-C was independently associated with occurrence of cardiac events in patients with coronary artery disease (1a) (P <0.05). Conclusions Serum levels of HDL-C and hs-CRP are independent risk factors for coronary heart disease. The level of HDL-C is closely related to the prognosis of patients with coronary heart disease.