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目的 探讨日常服用降压药的原发性高血压患者醛固酮/肾素比值（ARR）与夜间血压的相关性。方法 入选研究对象179（男88，女91）例，按ARR采用中位数（M）分为2组，比较2组的日间收缩压（DSBP）、日间舒张压（DDBP）、夜间收缩压（NSBP）、夜间舒张压（NDBP）以及在服药物、血钾、血钠等指标。结果 2组中NSBP、NDBP、血钾、血钠有显著性差异（均P<0.05，P<0.01），而性别、年龄、糖尿病、吸烟、体质量指数、DSBP、DDBP以及服用降压药物的差异均无统计学意义。同时校正了相关因素后，ARR与NSBP、NDBP、血钠呈正相关（r=0.528、r=0.481、r=0.342，均P<0.05），而与血钾呈负相关（r=-0.354，P<0.05）。多因素Logistic回归分析显示NSBP、NDBP均是ARR的独立相关因素（P<0.05），0R值分别为1.094（95%CI:0.906-1.205）、1.150（95%CI:0.919-1.445）。结论 原发性高血压患者中ARR与夜间血压显著相关。
Objective To investigate the correlation between aldosterone / renin ratio (ARR) and nocturnal blood pressure in patients with essential hypertension who are taking daily antihypertensive drugs. Methods A total of 179 subjects (88 male and 91 female) were enrolled and divided into two groups according to the median of the ARR (M). The daytime systolic blood pressure (DSBP), diastolic blood pressure (DDBP), nighttime contraction Pressure (NSBP), nocturnal diastolic blood pressure (NDBP) and in the medication, serum potassium, serum sodium and other indicators. Results There were significant differences in NSBP, NDBP, serum potassium and serum sodium between the two groups (P <0.05, P <0.01), while gender, age, diabetes, smoking, body mass index, DSBP and DDBP The difference was not statistically significant. ARR was positively correlated with NSBP, NDBP and serum sodium (r = 0.528, r = 0.481, r = 0.342, both P <0.05), but negatively correlated with serum potassium (r = -0.354, P < ; 0.05). Multivariate Logistic regression analysis showed that both NSBP and NDBP were independent correlates of ARR (P <0.05), with OR values of 1.094 (95% CI: 0.906-1.205) and 1.150 (95% CI: 0.919-1.445), respectively. Conclusions There is a significant correlation between ARR and nocturnal blood pressure in patients with essential hypertension.