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目的：用肺表面活性物质（PS）治疗肺灌洗兔急性呼吸窘迫综合征（ARDS）。方法：PS经气管插管注入肺内，分100mg·kg－1、150mg·kg－1和200mg·kg－1三个单次剂最组及100mg·kg－1×2、150mg·kg－1×2二个多次剂量组。结果：给PS后15分钟各治疗组PaO2显著增高，随后PaCO2下降、pH上升，肺顺应性改善，肺病理变化明显减轻。高剂量组疗效较低剂量组好，多次给药组较单次给药组好。结论：PS对肺灌洗兔ARDS有显著疗效。
OBJECTIVE: To treat pulmonary lavage acute respiratory distress syndrome (ARDS) with pulmonary surfactant (PS) in rabbits. Methods: PS was injected intratracheally into the lungs through the endotracheal tube and divided into three groups: 100mg · kg-1, 150mg · kg-1 and 200mg · kg-1 and 100mg · kg-1 × 2,150mg · kg-1 × 2 two multiple dose groups. Results: PaO2 was significantly increased in each treatment group 15 minutes after PS, then PaCO2 decreased, pH increased, lung compliance improved, and pulmonary pathology changed significantly. The high-dose group was better than the low-dose group, and the multiple-dose group was better than the single-dose group. Conclusion: PS has a significant effect on lung lavage ARDS in rabbits.