生物反应修饰物(Biological response modifier,BRM)是一类具有多种生物活性的物质,其作用包括调节免疫应答和增强机体的抗肿瘤能力。近年来对这类物质的研究引起了人们极大的兴趣。BRM的来源包括微生物。在日本,从链球菌培养物中提取的BRM有Bestatin和OK-432,并已成为常用的免疫治疗剂和抗肿瘤药,疗效较好。 国内目前也在积极研究多种BRM。我国新近开发的多抗甲素就是其中之一。70年代,西安医学院方亮教授在预防克山病的研究中,注意到克山病患者上呼吸道甲型链球菌感染率高而肿瘤发病率较低,因而推测链球菌代谢产物中可能存在抗癌物质,并对预防克山病制剂链球菌F和X抗原疫苗作了抗癌试验,结果发现这些抗原对小鼠肉瘤S180有较强抑制作用。随后,他们与四川抗菌素工业研究所等许多单位协作,进行了广泛深入的研究,结果开发出了一种新的免疫促进剂——多抗甲素(PolyactinA,PAA)。目前的 Biological response modifiers (BRMs) are a group of substances with a variety of biological activities. Their functions include modulating the immune response and enhancing the anti-tumor ability of the body. In recent years, the research on this kind of matter has aroused great interest. Sources of BRM include microorganisms. In Japan, BRM extracted from streptococcal cultures has Bestatin and OK-432 and has become a commonly used immunotherapeutic and antineoplastic agent with good efficacy. Domestic is also actively studying a variety of BRM. Our newly developed multi-anti-A is one of them. In the 1970s, Professor Fang Liang of Xi’an Medical College, in the study of prevention of Keshan disease, noticed that Keshan disease had a high prevalence of streptococcus pneumoniae in the upper respiratory tract and a low incidence of cancer, suggesting that there may exist anti-streptococcal metabolites Cancer substances, and to prevent Keshan disease agents Streptococcus F and X antigen vaccine made anti-cancer test and found that these antigens have a strong inhibitory effect on mouse sarcoma S180. Subsequently, they conducted extensive and in-depth research in collaboration with many units such as the Sichuan Institute of Antibiotics, and as a result developed a new immunostimulant, Polyactin A (PAA). current