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本研究探讨一氧化氮(NO)与小儿系膜增殖性肾小球肾炎(MsPGN)发病的关系。本组系膜增殖性肾小球肾炎28例,对照组25例,采用重氮化反应法测定MsPGN患者血清、尿中NO代谢产物水平。实验结果证明,MsPGN组血中NO水平与对照组无明显差异,但尿中NO水平明显低于对照组,MsPGN患者肾组织内产生NO能力处于抑制或缺陷状态。
This study was to investigate the relationship between nitric oxide (NO) and the incidence of mesangial proliferative glomerulonephritis (MsPGN) in children. The mesangial proliferative glomerulonephritis in 28 cases, the control group of 25 cases, the diazotization reaction in patients with MsPGN serum and urine levels of NO metabolites. The experimental results show that NO levels in serum of MsPGN group are not significantly different from those in control group, but the level of NO in urine is significantly lower than that of control group. The NO production in kidney tissue of MsPGN patients is in the state of inhibition or defect.