Objective: The aim of the study was to analyze the incidence, mortality and their impact factors and changing trends of malignant tumors in 2010 in the residents of Hai’an county, Jiangsu Province, China. Methods: Using the information of incidence, death registration information database and population data of malignant tumors in 2010 in the residents of Hai’an county, the incidence, mortality, accumulation incidence rates, and truncated incidence rate of malignant tumors were statistically analyzed. Results: The crude incidence, China standardized and world standardized incidence rates of malignant tumors in 2010 in Hai’an county were 281.53 per 100000 persons, 174.96 per 100 000 persons, and 175.14 per 100000 persons, respectively. The cumulative incidence rate from aged 0 to 64 years, the cumulative incidence rate from aged 0 to 74 years and the truncated incidence rate from aged 35 to 64 years were 6.85%, 15.39%, and 193.26 per 100000 persons, respectively. The rough mortality rate, China standardized and world standardized incidence rates were 234.11 per 100000 persons, 145.30 per 100000 persons, and 144.77 per 100000 persons, respectively. The top five cancers in the spectrum of cancer incidence were respectively esophageal cancer, lung cancer, stomach cancer, liver cancer, and colorectal cancer. The top four cancers in the spectrum of cancer death were consistent with the spectrum of cancer incidence. The 5th cancer in the spectrum of cancer death was pancreatic cancer. The incidence and mortality of various age groups were at a low level before 35-year-old age group. The incidence of female was slightly higher than that of male. But the incidence and mortality from the age group of 50 showed “suddenly” upward trend with age. The incidence and mortality of male were significantly higher than those of female. The ratios of male to female of incidence and mortality were 1.52:1 and 1.67:1, respectively. Conclusion: Residents over the age of 50, especially males, are high-risk groups who are exposed to certain risk factors. They should be the key objects of prevention and treatment of malignant tumors. Objective: The aim of the study was to analyze the incidence, mortality and their impact factors and changing trends of malignant tumors in 2010 in the residents of Hai’an county, Jiangsu Province, China. Methods: Using the information of incidence, death registration information database and population data of malignant tumors in 2010 in the residents of Hai’an county, the incidence, mortality, accumulation incidence rates, and truncated incidence rate of malignant tumors were physically analyzed. Results: The crude incidence, China standardized and world standardized incidence rates of malignant tumors in 2010 in Hai’an county were 281.53 per 100000 persons, 174.96 per 100 000 persons, and 175.14 per 100000 persons, respectively. The cumulative incidence rate from aged 0 to 64 years, the cumulative incidence rate from aged 0 to 74 years and the truncated incidence rate from 35 to 64 years were 6.85%, 15.39%, and 193.26 per 100000 persons, respectively. The rough mortali ty rate, China standardized and world standardized incidence rates were 234.11 per 100000 persons, 145.30 per 100000 persons, and 144.77 per 100000 persons, respectively. The top five cancers in the spectrum of cancer incidence were respectively esophageal cancer, lung cancer, stomach cancer, The cancer and the colorectal cancer. The top four cancers in the spectrum of cancer death were consistent with the spectrum of cancer incidence. The 5th cancer in the spectrum of cancer death was pancreatic cancer. The incidence and mortality of various age groups were at a The incidence of female was slightly higher than that of male. But the incidence and mortality from the age group of 50 showed “suddenly ” upward trend with age. The incidence and mortality of Male ratios were higher than those of female. The ratios of male to female of incidence and mortality were 1.52: 1 and 1.67: 1, respectively. Conclusion: Residents over the age of 50, especial ly males, are high-risk groups who are exposed to certain risk factors. They should be the key objects of prevention and treatment of malignant tumors.