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许多胰和胃肠激素对胆汁分泌有重要影响,药用量的胰岛素和高血糖素能减少狗的磷脂质和胆固醇分泌,作者研究证实循环中的胰岛素和高血糖素含量在生理范围内变动对狗的胆汁流量有影响.实验是将激素输入门脉系统,并使门脉和周围静脉血的激素浓度处于生理范围内,为查明对胆汁脂质分泌的影响,测定了胆盐、胆固醇和胆汁标本的磷脂质含量.将5条犬麻醉,结扎胆囊管,以导管插入总胆管远端.向门静脉、肠系膜静脉和肢体浅静脉插管以便取血和输液.为刺激胆汁流量在实验中输入牛磺胆酸钠,速度是18μmol/分.静脉注射溴化甲基派苯偶酯,初量是0.5mg/kg,间隔20分钟再给0.1mg/
Many pancreatic and gastrointestinal hormones have a significant effect on bile secretion. The amount of insulin and glucagon used to reduce dog phospholipids and cholesterol secretion, the authors study confirmed circulating changes in the physiological range of insulin and glucagon content of Dog’s bile flow rate is affected.Experiment is to enter the portal system of hormones, and the portal vein and peripheral venous blood hormone concentrations within the physiological range, in order to ascertain the impact on bile lipid secretion, determination of bile salts, cholesterol and Phospholipid content in bile specimens. Five dogs were anesthetized, the cystic duct was ligated, the catheter was inserted into the distal end of the common bile duct, and the portal vein, mesenteric vein and superficial vein were cannulated for blood and infusion. Sodium taurocholate, the speed is 18μmol / min intravenous methylphenidate bromide, the initial amount is 0.5mg / kg, 20 minutes interval to give 0.1mg /