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本实验在青霉素致痫大鼠模型上观察海马内微量注射半胱胺降低生长抑素后，癫痫发作强度和脑电总功率的变化，并用免疫组化和ＨＰＬＣ方法检测中缝背核５－ＨＴ、蓝斑核ＮＥ免疫阳性物质和海马内ＮＥ含量。结果发现致痫后２ｈ５－ＨＴ、ＮＥ免疫阳性物质显著减少（Ｐ＜０．０５），海马灌流液中ＮＥ含量增加（Ｐ＜０．０５），半胱胺降低海马内生长抑素３０％后，癫痫发作程度减轻，５－ＨＴ、ＮＥ免疫阳性物质和海马ＮＥ含量与对照组相比无显著改变（Ｐ＞０．０５），提示海马内ＳＳ有致痫作用，并可能促进５－ＨＴ、ＮＥ的释放。
In this study, we observed the change of epileptic seizure intensity and total electroencephalogram (EEG) power in hippocampus after injection of cysteamine in penicillin-induced epilepsy rat model. Immunohistochemistry and HPLC were used to detect 5-HT, Locus coeruleus NE immunoreactive substances and NE content in the hippocampus. The results showed that the immunoreactive substances of 5-HT and NE were significantly decreased (P <0.05) at 2h after epileptic seizure, the content of NE in hippocampal perfusate increased (P <0.05), Cysteamine decreased the content of somatostatin in hippocampus by 30% (P> 0.05), suggesting that epilepsy may be induced by SS in the hippocampus, which may promote the increase of 5-HT, NE-positive immunoreactive substances and NE in the hippocampus Release.