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目的分析中药血必净注射液在预防胸部恶性肿瘤放疗急性放射性肺损伤中的临床效果。方法 38例胸部恶性肿瘤患者,随机分为观察组(20例)与对照组(18例)。观察组采用放疗联合血必净注射液,对照组采用单纯放疗,两组患者在治疗期间均采用的是调强适型放疗。治疗完成之后对两组患者的临床治疗效果进行对比分析。结果放疗40 Gy、放疗后观察组患者血小板衍生生长因子(PDGF)明显低于对照组,差异具有统计学意义(P<0.05),放疗40 Gy、放疗后、放疗结束后1个月、放疗结束后3个月观察组高迁移率族蛋白B1(HMGB1)明显低于对照组,差异具有统计学意义(P<0.05)。观察组放疗前后PDGF呈下降趋势;HMGB1呈上升趋势,但不如对照组明显。对照组放疗前后PDGF、HMGB1呈上升趋势。观察组出现2级以上急性放射性肺损伤发生率5.0%低于对照组38.9%,差异具有统计学意义(P<0.05)。结论对于血必净注射液,其在治疗急性放射性肺损伤疾病时具有较好的效果,且该治疗方法对患者的炎性因子水平具有较大的影响,能够有效预防患者出现急性放射性肺损伤。
Objective To analyze the clinical effect of Xuebijing injection in preventing radiation-induced acute lung injury of thoracic malignant tumors. Methods Thirty-eight patients with thoracic malignant tumor were randomly divided into observation group (20 cases) and control group (18 cases). The observation group was treated with radiotherapy combined with Xuebijing injection, while the control group received radiotherapy alone. Both groups received intensity-modulated radiotherapy during the treatment period. After the completion of treatment, the clinical effects of two groups of patients were compared. Results After radiotherapy 40 Gy, the PDGF level in the observation group was significantly lower than that in the control group (P <0.05), 40 Gy after radiotherapy, 1 month after radiotherapy and 1 month after radiotherapy After 3 months, the HMGB1 in observation group was significantly lower than that in control group (P <0.05). Before and after radiotherapy, PDGF showed a decreasing trend in the observation group; HMGB1 showed an upward trend but not as obvious as the control group. Before and after radiotherapy, the levels of PDGF and HMGB1 in the control group showed an upward trend. The incidence of acute radiation-induced lung injury of grade 2 or above in observation group was 5.0% lower than that in control group (38.9%), the difference was statistically significant (P <0.05). Conclusion Xuebijing injection has a good effect in the treatment of acute radiation-induced lung injury, and the treatment has a greater impact on the level of inflammatory cytokines in patients, which can effectively prevent acute radiation-induced lung injury in patients.