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为观察尼莫地平对偏头痛的疗效,我们将146例偏头痛病随机分两组治疗,其中尼莫地平(下称治疗组)96例,对照组50例。两组病人的性别、年龄及病程均有可比性。病人均有剧烈头痛,以跳痛、胀痛为主。 治疗方法及疗效:治疗组服用天津中央制药厂及山东新华制药厂生产的尼莫地平片,每次40～60mg,每日3次,12周为一疗程。对照组每次服用肠溶阿司匹林0.3g,安定2.5mg,均每日3次,12周为一疗程。 经用药一疗程后,治疗组显效49例,有效36例,无效11例,总有效率为88.5％;对照组分别为5、15、30例,总有效率仅40％。两组比较有非常显著差异(P<0 01)。在治疗组中,以典型偏头痛的疗效最好。治疗后随访0.5～1年,无一例复发。服用尼莫地平的病人中,有皮肤瘙痒者5例,眩晕3例,嗜睡1例,恶心2例,均较轻微,3～5天后均好转,不影响治疗。
In order to observe the effect of nimodipine on migraine, 146 migraine patients were randomly divided into two groups, 96 cases in nimodipine group and 50 cases in control group. Two groups of patients sex, age and duration are comparable. Patients have severe headache, to jump pain, pain-based. Treatment and efficacy: The treatment group taking Tianjin Central Pharmaceutical Factory and Shandong Xinhua Pharmaceutical Factory production of nimodipine tablets, each 40 ~ 60mg, 3 times a day, 12 weeks for a course of treatment. The control group took enteric-coated aspirin 0.3g and diazepam 2.5mg every time for three times daily for 12 weeks. After a course of treatment, the treatment group markedly effective in 49 cases, effective in 36 cases, ineffective in 11 cases, the total effective rate was 88.5%; control group were 5,15,30 cases, the total effective rate was only 40%. There was a significant difference between the two groups (P <0.01). In the treatment group, the best effect of typical migraine. Follow-up after treatment 0.5 to 1 year, no case of recurrence. Among the patients taking nimodipine, there were 5 cases of pruritus, 3 cases of dizziness, 1 case of drowsiness and 2 cases of nausea, all of which were mild and did not change after 3 ~ 5 days.