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氨基蝶环(Aminopterini)又名白血宁,为叶酸对抗物。Farber氏在1948年以之治疗小儿急性白血病获得暫时緩解,其奏效率約为30～40％,对于其他类型的贅生性疾病,偶可使症状減輕,故也有試用者,其毒性症状甚重,已为临床所重視,但毒性反应致死者,文献报导尚少。本文报导一例因口服氨基蝶环毒性反应致死者,以供参考。患者(住院号4997),女性,55岁,家庭主妇;因右側胸痛,发热約二月,于1962年5月9日入院治疗。 1961年5月經X綫透視发現有肺結核,此后常有咳嗽,有时有血痰。約二月前漸覚右側胸痛,发热、咳嗽、气促,入院前一月开始服異菸肼、对氨柳酸未見効。
Aminopterini (Aminopterini), also known as white blood Ning, folate antagonist. Farber’s treatment of childhood acute leukemia in 1948 to obtain temporary relief, the playing efficiency of about 30 to 40%, for other types of neoplastic diseases, even to alleviate the symptoms, it is also a trial of patients with severe toxicity symptoms, Has been clinically important, but the toxicity caused by death, there are few reports of the literature. This article reports a case of death caused by oral administration of aminopterin toxicity, for reference. Patient (hospital number 4997), female, 55 years old, housewife; fever due about right chest pain, February, 1962, admitted to hospital on May 9, May 1961 X-ray fluoroscopy found to be tuberculosis, coughing since then, and sometimes bloody sputum. About two months ago, gradually right chest pain, fever, cough, shortness of breath, in January before admission admission isoniazid, no effect on the salicylic acid.