[答]对此事实目前尚难以解释,个人认为可能有以下原因:一是青霉素大小抗原决定簇与蛋白结合成为抗原后,可刺激B淋巴细胞分化浆细胞,后者又产生大量免疫球蛋白E(IgE)或IgG、IgM。其中IgE为亲细胞抗体,可与许多组织周围的肥大细胞和血液中的嗜硷粒细胞的受体相结合,吸附于细胞表面,使该细胞处于致敏状态。当等二次抗原再进入抗体时,即能与IgE结合,激活鸟苷化酶,使环磷鸟苷(cGMP) [A] of this fact is difficult to explain, personally think there may be the following reasons: First, the size of penicillin antigen binding determinants and proteins to become antigen, can stimulate B lymphocytes differentiate plasma cells, which in turn produce a large number of immunoglobulin E (IgE) or IgG, IgM. IgE which is a pro-cell antibody, with many tissues around the mast cells and blood cells of the combination of basophils, adsorbed on the cell surface, so that the cells in a sensitized state. When the second antigen and then enter the antibody, that is, with IgE binding, activation of guanosidase, cyclophosphamide (cGMP)