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1986年,Sen和Baltimore首先从B淋巴细胞核抽提物中,检测到一种能与免疫球蛋白K链基因增强子KB序列(5'-GGGATTTCC-3)特异结合,并能促进。链基因表达的核蛋白因子,称之为核因子-KB(nuclear factor-kappa B,N
In 1986, Sen and Baltimore first detected a specific binding to the immunoglobulin K chain gene enhancer sequence (5’-GGGATTTCC-3) from B lymphocyte nuclear extracts and promoted it. The nuclear factor of chain gene expression, called nuclear factor-kappa B (N