Podocin是近年来在肾小球足突裂孔隔膜发现的一个跨膜蛋白 ,属Stomatin家族成员之一 ,具有促进信号传导功能及裂孔隔膜发育成熟的作用。Podocin参与肾小球滤过屏障的正常发育并维持其功能。在先天性与获得性肾病存在其基因或mRNA表达的异常 ,结果使滤过膜形态结构与屏障功能完整性破坏 ,导致大量蛋白尿。Podocin的发现为深入阐明蛋白尿形成机制有重要意义 Podocin is a transmembrane protein found in the glomerular foot process hippocampal septum in recent years. It belongs to the Stomatin family and plays a role in promoting signal transduction and the development of hiatus. Podocin participates in the normal development of the glomerular filtration barrier and maintains its function. In congenital and acquired nephropathy, there are abnormalities in gene or mRNA expression. As a result, the integrity of the membrane structure and barrier function are destroyed, resulting in a large amount of proteinuria. The discovery of Podocin is of great significance to clarify the mechanism of proteinuria