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目的：探讨冷凝手术治疗心肌梗死后室性心动过速的病理基础及冷凝手术中影响冷凝消融作用的各种因素。方法：对７条犬行心外膜冷凝，５条犬行心内膜冷凝，另１０条犬建立心肌梗死模型，诱发出２０次室性心动过速，并用冷凝予以终止。心外膜冷凝犬行２４小时动态心电图（Ｈｏｌｔｅｒ）监测，所有犬均行病理检查。结果：心外膜冷凝时，冷凝时间主要影响冷凝损伤灶的深度，冷凝次数主要影响冷凝损伤灶的直径。心内膜冷凝的损伤灶直径和深度均大于心外膜冷凝。冷凝损伤灶的演变过程可分为４期，冷凝损伤灶的特点可归纳为“匀”、“齐”、“明”、“整”。冷凝后即刻心肌肌原纤维即发生不可逆性溶解，而间质细胞受损较轻，后期可以修复。冷凝后１周内心律失常均自行消失。结论：冷凝消融的病理特点说明冷凝可有效地消融位于心室不同部位的室性心动过速病灶，而冷凝灶修复后无致心律失常的作用。
Objective: To investigate the pathological basis of the surgical treatment of ventricular tachyarrhythmias after myocardial infarction and the various factors affecting the ablation and ablation in the coagulation surgery. Methods: Seven dogs were subjected to epicardial condensation, five dogs were subjected to endocardial condensation, and the other ten dogs were established myocardial infarction model. Twenty ventricular tachycardia were induced and terminated by condensation. Epicardial canine congenital 24-hour Holter monitoring, all dogs underwent pathological examination. Results: When the epicardial is condensed, the condensation time mainly affects the depth of the condensation lesion. The number of condensation mainly affects the diameter of the condensation lesion. Endocardial condensation lesion diameter and depth are greater than epicardial condensation. Condensation lesion evolution can be divided into four stages, the characteristics of condensation lesions can be summarized as “uniform”, “Qi”, “Ming”, “whole.” Immediately after condensation, myocardial myofibrils irreversibly dissolve, whereas interstitial cells are less damaged and can be repaired later. One week after condensation, arrhythmias disappear on their own. Conclusion: The pathological characteristics of the coagulation and ablation show that condensation can effectively abate ventricular tachycardia lesions located in different parts of the ventricle, and the coagulation stove repair without arrhythmia.