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为探讨国产依诺沙星（ Ｅ Ｎ Ｘ）对大鼠血浆茶碱（ Ｔ Ｐ）药动学的影响，给临床合理使用 Ｅ Ｎ Ｘ 提供实验依据。经灌胃给予大鼠单剂量 Ｔ Ｐ２０ｍ ｇ／ｋｇ，同时给予 Ｅ Ｎ Ｘ （３００ｍ ｇ／ｋｇ 及４５０ｍ ｇ／ｋｇ）３次，用 Ｈ Ｐ Ｌ Ｃ法测定给 Ｔ Ｐ后１、２、３、５、７、１２、２４小时的血浆 Ｔ Ｐ浓度。结果显示茶碱以一室药动学模型消除， Ｅ Ｎ Ｘ 使 Ｔ Ｐ浓度明显升高， Ｔ１／２ β延长， Ａ Ｕ Ｃ增大，血浆清除率下降，具有剂量依赖性。由此表明国产 Ｅ Ｎ Ｘ 与 Ｔ Ｐ有明确的相互作用，合用时应予以注意。
To investigate the effect of enoxacin (E N X) on the pharmacokinetics of plasma theophylline (TP) in rats and to provide an experimental basis for the rational use of E N X in clinical practice. Rats were given a single dose of T P20m g / kg by gavage, while E N X (300m g / kg and 450m g / kg) was administered three times. Hp L C was used to determine the T, Plasma Tp concentrations were measured at 5, 7, 12, 24 hours. The results showed that theophylline was eliminated in a one-compartment pharmacokinetic model. E N X increased the concentration of T P, prolonged T1 / 2 β, increased A U C and decreased plasma clearance in a dose-dependent manner. This shows that domestic E N X and T P have a clear interaction, should be used together.